Chemical Structure : OAT-4828
CAS No.:
2947497-65-4
OAT-4828
(OAT4828)
Catalog No.: PC-25570Not For Human Use, Lab Use Only.
OAT-4828 is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
OAT-4828 is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system).
OAT-4828 shows high selectivity against other deubiquitinases at 10 uM.
OAT-4828 inhibits the Wnt/β-catenin pathway with EC50 at 0.15 uM in human CRC cells of the SW480 cell line.
OAT-4828 prolongs survival of B16F10-bearing mice and boosts T-cell antitumor activity.
OAT-4828 reshapes the tumor microenvironment and promotes the antitumor function of myeloid cell subpopulations.
T Cells are crucial for OAT-4828 antitumor activity, which can be further improved by anti-PD-1 treatment.
OAT-4828 activates human T cells by increasing NFATC2 activity and MDM2 downregulation.
Physicochemical Properties
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M.Wt
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571.62
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Formula
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C28H28F3N5O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6,6-dimethyl-3-((7-(4-methyl-3-((S)-3-(methylamino)pyrrolidine-1-carbonyl)-6-(trifluoromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-2-yl)methyl)-3-azabicyclo[3.1.0]hexane-2,4-dione
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References
1. Muchowicz A, et al. J Immunother Cancer. 2025 Sep 25;13(9):e012287.
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