UC495 | OTULIN inhibitor | Probechem Biochemicals

Chemical Structure : UC495

UC495 (UC-495)

Catalog No.: PC-26283Not For Human Use, Lab Use Only.

UC495 is a specific small molecule inhibitor of deubiquitinase OTULIN, interacts with the OTULIN deubiquitinase binding pocket.

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Biological Activity

UC495 is a specific small molecule inhibitor of deubiquitinase OTULIN, interacts with the OTULIN deubiquitinase binding pocket.
UC495 selectively decreases phosphorylated tau at AT8 site in sAD2.1 iPSNs.
UC495 decreases tau levels in in human neuroblastoma cell line, SH-SY5Y.

Physicochemical Properties

M.Wt	678.77
Formula	C38H39FN6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((R)-3-(1H-imidazol-4-yl)-1-(((S)-1-(methylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-3-(4-fluorophenyl)-2-(3-(4-hydroxyphenyl)propanamido)propanamide

References

1. Tangavelou K, et al. Genom Psychiatry. 2025 Nov 29;1(6):48-58.

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UC495 (UC-495)

Biological Activity

Physicochemical Properties

References

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