Chemical Structure : BB07CA902
CAS No.:
BB07CA902
Catalog No.: PC-25852Not For Human Use, Lab Use Only.
BB07CA902 is a potent, specific, covalent inhibitor of interferon-stimulated gene 15 (ISG15) protease murine USP18 (mUSP18) with IC50 of 35 nM, effectively increases ISGylation levels in cells by inhibiting mUSP18 activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BB07CA902 is a potent, specific, covalent inhibitor of interferon-stimulated gene 15 (ISG15) protease murine USP18 (mUSP18) with IC50 of 35 nM, effectively increases ISGylation levels in cells by inhibiting mUSP18 activity.
showed full mUSP18 specificity amongst a panel of 41 DUBs.
BB07CA902 covalently inhibits mUSP18 with an enzyme inactivation rate (kinact) over inhibition constant (Ki) ratio (kinact/Ki) of 4646 M−1s−1.
BB07CA902 is less potent toward human USP18 with IC50 of 1.2 uM.
BB07CA902 significantly elevated cellular ISGylation in a dose-dependent manner, and a maximum accumulation of ISGylation reached 10 µM.
BB07CA902 does not inhibit human USP18 in cells.
BB07CA902 inhibits in-cell mUSP18/ISG15 interaction in a dose-dependent manner with IC50 of 2.0 uM, does not inhibit the interactions of hUSP18 with ISG15 and STAT2.
Physicochemical Properties
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M.Wt
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311.43
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Formula
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C19H25N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((3aR,5s,6aS)-2-cyanooctahydrocyclopenta[c]pyrrol-5-yl)-4-isopropyl-3-methylbenzamide
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References
1. Kooij R, et al. Angew Chem Int Ed Engl. 2025 Oct 7:e202510941.
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