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Chemical Structure : KY-02061
Catalog No.: PC-63513Not For Human Use, Lab Use Only.
KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay.
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KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay.
KY-02061 increases the activation of the Wnt/β-catenin pathway in a dose-dependent manner as revealed by the TOPflash reporter assay.
ALP activity also increased in a dose‐dependent manner in KY-02061-treated primary osteoblast cells.
KY-02061 increases levels of Runx2, an osteoblast differentiation marker, and β-catenin
| M.Wt | 445.486 | |
| Formula | C22H23NO7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87.
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