NSC 668036 is a specific inhibitor of the Dishevelled (Dvl) PDZ domain, extremely weakly binds to PSD-95, PSD95, and PDZ7 domain of GRIP.
NSC 668036 inhibits the signaling induced by Wnt3A and blocks Wnt signaling by interrupting the Fz-Dvl interaction.
NSC 668036 suppresses β-catenin-driven gene transcription and abolishes TGF-β1-induced migration, expression of collagen I and α-α-SMA in fibroblasts.
NSC 668036 depresses fibrotic process in vivo.
