NPL-4011 | Dvl1-PDZ inhibitor | Probechem Biochemicals

Chemical Structure : NPL-4011

NPL-4011 (NPL4011)

Catalog No.: PC-49500Not For Human Use, Lab Use Only.

NPL-4011 is a specific small molecule inhibitor of PDZ domain of human Dvl1 (Dvl1-PDZ) with KD vaule of 34.5 uM in NMR titration experiments.

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Biological Activity

NPL-4011 is a specific small molecule inhibitor of PDZ domain of human Dvl1 (Dvl1-PDZ) with KD vaule of 34.5 uM in NMR titration experiments.
NPL-4011 is a stronger inhibitor than CalBioChem-322338 (KD=954 uM).
NPL-4011 (100 uM) demonstrated cell proliferation inhibition of BT-20 triple negative breast cancer cell.

Physicochemical Properties

M.Wt	582.61
Formula	C33H30N2O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-methylenebis(2-(2-(m-tolyloxy)acetamido)benzoic acid)

References

1. Hori K, et al. Front Pharmacol. 2018 Sep 5;9:983.

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NPL-4011 (NPL4011)

Biological Activity

Physicochemical Properties

References

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