| Cat. No. |
Product Name |
Information |
| PC-21340 |
DS21150768
HPK1/MAP4K1 inhibitor
|
DS21150768 is a potent selective and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with IC50 of 3.27 nM in cell-free HPK1 assays, binds to HPK1 with an affinity constant (KD) of 6.08 nM. |
| PC-20029 |
F389-0746
MAP4K4 inhibitor
|
F389-0746 is a potent, selective and orally active MAP4K4 inhibitor with IC50 of 120.7 nM. |
| PC-49661 |
BAY-405
HPK1/MAP4K1 inhibitor
|
BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor, displays potent nanomolar MAP4K1 inhibition in biochemical and cellular assays, inhibits SLP76 phosphorylation with submicromolar potency and shows good kinase selectivity. |
| PC-72305 |
ZYF0033
HPK1/MAP4K1 inhibitor
|
ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein. |
| PC-72304 |
GNE-1858
HPK1/MAP4K1 inhibitor
|
GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay. |
| PC-72303 |
A-745
HPK1/MAP4K1 inhibitor
|
A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM. |
| PC-72055 |
Compound K
HPK1/MAP4K1 inhibitor
|
Compound K (HPK1 inhibitor CompK) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family. |
| PC-72013 |
HPK1 inhibitor 1
HPK1/MAP4K1 inhibitor
|
HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM. |
| PC-36139 |
DMX-5804
MAP4K4 inhibitor
|
DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM. |
| PC-35005 |
MAP4K4-IN-37
MAP4K4 inhibitor
|
MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM. |
| PC-42954 |
HG6-64-1
TAK1/MAP4K2 inhibitor
|
HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively. |
| PC-62937 |
MAP4K4-IN-44
MAP4K4 inhibitor
|
MAP4K4-IN-44 is a potent, moderately selective small molecule MAP4K4 inhibitor with IC50 of 5 nM in LC3K assay, demonstrates favorable in vivo bioavailability in mouse. |
