| Cat. No. |
Product Name |
Information |
| PC-42954 |
HG6-64-1
TAK1/MAP4K2 inhibitor
|
HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively. |
| PC-62937 |
MAP4K4-IN-44
MAP4K4 inhibitor
|
MAP4K4-IN-44 is a potent, moderately selective small molecule MAP4K4 inhibitor with IC50 of 5 nM in LC3K assay, demonstrates favorable in vivo bioavailability in mouse. |
| PC-62936 |
GNE-220
MAP4K4 inhibitor
|
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM. |
| PC-62935 |
MAP4K4-IN-17
MAP4K4 inhibitor
|
MAP4K4-IN-17 is a potent and highly selective MAP4K4 inhibitor with IC50 of 14.9 nM, showes improved overall drug-like properties compared to PF-06260933. |
| PC-61694 |
PF-06260933 dihydrochloride
MAP4K4 inhibitor
|
PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM. |
| PC-61165 |
MAP4K4-IN-11e
MAP4K4 inhibitor
|
MAP4K4-IN-11e is a potent, selective, ATP-competitive inhibitor of MAP4K4 with IC50 of 1.9 uM, without effect on other stress pathway related kinases. |
| PC-60014 |
PF-06260933
MAP4K4 inhibitor
|
PF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM. |
| PC-42105 |
GNE-495
MAP4K4 inhibitor
|
GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM. |
| PC-23624 |
Prostetin-12k
MAP4K inhibitor, MLK3 inhibitor
|
Prostetin/12k is a highly potent, blood-brain barrier-penetrant inhibitor of mitogen-activated protein kinase kinase kinase kinase (MAP4K) family with IC50 of 0.3 nM for HGK (MAP4K4) and 23.7 nM for MLK3. |
| PC-23589 |
PF-07265028
HPK1 inhibitor
|
PF-07265028 is a potent, selective hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with Ki of <0.05 nM, and cellular IC50 of 17 nM (pSLP76 inhibition). |
| PC-23066 |
BGB-15025
HPK1 inhibitor
|
BGB-15025 is a potent and selective hematopoietic progenitor kinase 1 (HPK1) inhibitor with biochemical IC50 of 1.04 nM. |
| PC-23064 |
GNE-6893
HPK1 inhibitor
|
GNE-6893 is a potent, selective and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1) with Ki of <0.019 nM, potently inhibits phosphorylation of SLP76 with IC50 of 44 nM in Jurkat cell assay. |
