Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-MAP4K-PF-06260933 dihydrochloride
PF-06260933 dihydrochloride

Chemical Structure : PF-06260933 dihydrochloride

CAS No.: 1883548-86-4

Add to Favorites

PF-06260933 dihydrochloride (PF 06260933 dihydrochloride)

Catalog No.: PC-61694Not For Human Use, Lab Use Only.

PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.

Packing Price Stock Quantity
10 mg Get quote
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
PF-06260933 dihydrochloride possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization.
PF-06260933 dihydrochloride significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.

Physicochemical Properties

M.Wt 369.67
Formula C16H15Cl3N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride

References

1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.

2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: