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MAP4K4-IN-37

Chemical Structure : MAP4K4-IN-37

CAS No.: 2089334-01-8

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MAP4K4-IN-37

Catalog No.: PC-35005Not For Human Use, Lab Use Only.

MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.
    MAP4K4-IN-37 inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM).
    MAP4K4-IN-37 possesses a high degree of kinome selectivity against a set of 244 kinases.
    MAP4K4-IN-37 shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice

    Physicochemical Properties

    M.Wt 382.844
    Formula C21H19ClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-{4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]phenoxy}-2-methylpropanoic acid

    References

    1. Dow RL, et al. J Med Chem. 2018 Apr 12;61(7):3114-3125.

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