GNE-495 |CAS:1449277-10-4 Probechem Biochemicals

Chemical Structure : GNE-495

CAS No.: 1449277-10-4

GNE-495 (GNE 495;GNE495)

Catalog No.: PC-42105Not For Human Use, Lab Use Only.

GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$158	In stock
25 mg	$258	In stock
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Biological Activity

GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.
GNE-495 exhibits adequate potency preventing migration of HUVEC cells in vitro (IC50=57 nM).
GNE-495 has good PK and demonstrates in vivo efficacy in a retinal angiogenesis model .

Physicochemical Properties

M.Wt	405.4249
Formula	C22H20FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: 10 mg/mL
Chemical Name/SMILES	1,7-Naphthyridine-5-carboxamide, 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-

References

1. Ndubaku CO, et al. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.

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GNE-495 (GNE 495;GNE495)

Biological Activity

Physicochemical Properties

References

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