PF-06260933 (PF06260933, PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.
PF-06260933 demonstrates very good selectivity against more than 150 native kinases, with only the closely related GCK family members (ZC2, TNIK and ZC3, MINK 70% inhibition at 1 uM).
PF-06260933 inhibits LPS-induced plasma TNFα levels in mouse model.
Physicochemical Properties
M.Wt
296.754
Formula
C16H13ClN4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-(4-chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine
References
1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.
2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.
