MAP4K4-IN-11e |CAS:1774346-60-9 Probechem Biochemicals

Chemical Structure : MAP4K4-IN-11e

MAP4K4-IN-11e (MAP4K4 inhibitor 11e)

Catalog No.: PC-61165Not For Human Use, Lab Use Only.

MAP4K4-IN-11e is a potent, selective, ATP-competitive inhibitor of MAP4K4 with IC50 of 1.9 uM, without effect on other stress pathway related kinases.

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Biological Activity

MAP4K4-IN-11e is a potent, selective, ATP-competitive inhibitor of MAP4K4 with IC50 of 1.9 uM, without effect on other stress pathway related kinases.
MAP4K4 is active at much lower concentration in the cellular neurite outgrowth assay and may exhibit better pharmacokinetic properties.

Physicochemical Properties

M.Wt	301.342
Formula	C17H19NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-hexanoyl-4-hydroxy-5-(4-hydroxyphenyl)pyridin-2(1H)-one

References

1. Schröder P, et al. Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12398-403.

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MAP4K4-IN-11e (MAP4K4 inhibitor 11e)

Biological Activity

Physicochemical Properties

References

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