Catalog No.: PC-62936Not For Human Use, Lab Use Only.
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.
GNE-220 alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions。
GNE-220 dose-dependently increases the number of β1-integrin in long focal adhesions.
