Catalog No.: PC-23370Not For Human Use, Lab Use Only.
NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with biochemicals IC50 of 0.7 nM and cellular IC50 of 41 nM.
NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with biochemicals IC50 of 0.7 nM and cellular IC50 of 41 nM.
NDI-101150 displays >400-fold selectivity over closely related MAP4K family members.
NDI-101150 could overcome the immunosuppressive effects of prostaglandin E2, adenosine, and TGF-β on human T cell activation, also directly limits the suppressive capacity of T regulatory cells.
NDI-101150 significantly enhanced the production of antigen-specific antibodies in response to immunization with both T-dependent and T-independent antigens, while anti-PD1 treatment had minimal to no effects on antibody production.
NDI-101150 or anti-PD1 treatments alone induced tumor growth inhibition in the murine CT-26 syngeneic tumor model, NDI-101150 and anti-PD1 in combination mediated complete tumor regressions in several mice.
