TK-850 | TGF-βR1/MAP4K4 | Probechem Biochemicals

Chemical Structure : TK-850

TK-850 (TK850)

Catalog No.: PC-25408Not For Human Use, Lab Use Only.

TK-850 is a potent, dual inhibitor of transforming growth factor-β receptor 1 (TGF-βRI, TGFBR1) and mitogen-activated protein 4 kinase 4 (MAP4K4) with binding Kd of 4.5 nM and 1.4 nM respectively.

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Biological Activity

TK-850 is a potent, dual inhibitor of transforming growth factor-β receptor 1 (TGF-βRI, TGFBR1) and mitogen-activated protein 4 kinase 4 (MAP4K4) with binding Kd of 4.5 nM and 1.4 nM respectively.
TK-850 reduces renal fibrosis in a unilateral ureteral obstruction mouse model by lowering hydroxyproline and tissue inhibitor of metalloproteinase 1 levels without impacting body weight or mortality.
TK-850 demonstrates the antifibrotic properties in mouse model of unilateral ureteral obstruction (UUO).

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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TK-850 (TK850)

Biological Activity

Physicochemical Properties

References

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