Chemical Structure : GNE-6893
CAS No.:
2415374-98-8
GNE-6893
(GNE6893)
Catalog No.: PC-23064Not For Human Use, Lab Use Only.
GNE-6893 is a potent, selective and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1) with Ki of <0.019 nM, potently inhibits phosphorylation of SLP76 with IC50 of 44 nM in Jurkat cell assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GNE-6893 is a potent, selective and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1) with Ki of <0.019 nM, potently inhibits phosphorylation of SLP76 with IC50 of 44 nM in Jurkat cell assay.
GNE-6893 potently elevates IL2 secretion with EC50 of 6.4 nM in primary human T-cells stimulated with anti-CD3 and anti-CD28.
GNE-6893 exhibits high kinase selectivity and robust activation of T-cell signaling, as well as favorable pharmacokinetic and in vitro safety profiles.
Physicochemical Properties
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M.Wt
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453.47
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Formula
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C23H24FN5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3R,4S)-4-methyltetrahydrofuran-3-yl (8-amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl)carbamate
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References
1. Tellis JC, et al. ACS Med Chem Lett. 2024 Sep 3;15(9):1606-1614.
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