| Cat. No. |
Product Name |
Information |
| PC-38587 |
L557-0155
VSIG-8/VISTA inhibitor
|
L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth. |
| PC-38146 |
VISTA inhibitor III
VISTA inhibitor
|
VISTA inhibitor III is a small-molecule ligand for immune checkpoint VISTA with IC50 of 480 nM in FRET assay. |
| PC-38145 |
NSC622608
VISTA inhibitor
|
NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay. |
| PC-35927 |
RRx-001
CD47-SIRPα inhibitor
|
RRx-001 (RRx001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α. |
| PC-62015 |
DRI-C21045
CD40-CD40L inhibitor
|
DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays. |
| PC-25880 |
BPU11
CD28 inhibitor
|
BPU11 is a specific small molecule CD28 inhibitor targeting CD28 costimulation with Kd of 6.5 uM, disrupts CD28-B7 interactions across biochemical and cellular systems. |
| PC-25821 |
LAGi-DEL
LAG-3 inhibitor
|
LAGi-DEL is a potent small molecule LAG-3 inhibitor, binds directly to LAG-3 with Kd value of 97 nM (SPR) and 271 nM (MST), disrupts the LAG-3/MHC-II interaction with EC50 of 138 nM. |
| PC-25773 |
CliMB-325
MHC‑I inducer
|
CliMB-325 is a small molecule modulator/ inducer of MHC‑I surface expression, induces MHC-I surface expression levels in CT26 cells with EC50 of 498 nM, also enhances T cell activation and exhibits lower toxicity. |
| PC-25299 |
19MS-5
CD28 inhibitor
|
19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays. |
| PC-25298 |
5MS-5
CD28 inhibitor
|
5MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=50.32 uM) and potent inhibition of CD28-B7 interactions with IC50 of 10.32 uM in cellular reporter assays. |
| PC-25252 |
CD28 inhibitor 22VS
CD28 inhibitor
|
CD28 inhibitor 22VS is a selective small molecule CD28 inhibitor with IC50 of 7.8 uM in ELISA-based CD28:B7-1 (CD80) interaction assays, binds directly to CD28 with MST Kd of 52.45 uM. |
| PC-24096 |
VISTA inhibitor A4
VISTA inhibitor
|
VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM. |
