Chemical Structure : VISTA inhibitor A4
CAS No.:
2994662-45-0
VISTA inhibitor A4
Catalog No.: PC-24096Not For Human Use, Lab Use Only.
VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM.
A4 (0.1-5 uM) blocks the VISTA signaling pathway in PBMCs, enhances IFN-γ release, also restores TNF-α release, enhances the killing ability of PBMCs against tumor cells.
A4 significantly activated peripheral blood mononuclear cells (PBMCs) induced the release of cytokines such as IFN-γ and enhanced the cytotoxicity of PBMCs against tumor cells.
A4 displayed potent antitumor activity and synergized with PD-L1 antibody to enhance the therapeutic effect against cancer.
Physicochemical Properties
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M.Wt
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290.32
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Formula
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C14H18N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((4-(((2-hydroxyethyl)amino)methyl)-6-methoxypyrimidin-2-yl)amino)phenol
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References
1. Sun C, et al. J Med Chem. 2024 Mar 14;67(5):3590-3605.
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