| Cat. No. |
Product Name |
Information |
| PC-21817 |
MTX-3937
Siglec-9 inhibitor
|
MTX-3937 is a small-molecule Siglec-9 inhibitor with binding KD of 3.15 uM in BLI assay, inhibits phosphorylation of Siglec-9 and downstream SHP1 and SHP2. |
| PC-21257 |
VISTA inhibitor compound 1
VISTA inhibitor
|
VISTA inhibitor compound 1 is a bifunctional inhibitor targeting VISTA, shows good binding affinity with VISTA (SPR KD=256 nM), induces potent VISTA degradation in HepG2 cells and activates antitumor immunity. |
| PC-21024 |
TIM-3 inhibitor 38
TIM-3 inhibitor
|
TIM-3 inhibitor 38 is a small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with Ki of 70 nM in FPA competition assays. |
| PC-21023 |
TIM-3 inhibitor A-41
TIM-3 inhibitor
|
TIM-3 inhibitor A-41 is small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with SPR Kd value of 0.61 uM. |
| PC-38590 |
VISTA inhibitor M351-056
VISTA inhibitor
|
VISTA inhibitor M351-056 is a small molecule compound having affinity with VISTA. |
| PC-38588 |
Compound 6809-0223
VISTA inhibitor
|
Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD). |
| PC-38587 |
L557-0155
VSIG-8/VISTA inhibitor
|
L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth. |
| PC-38146 |
VISTA inhibitor III
VISTA inhibitor
|
VISTA inhibitor III is a small-molecule ligand for immune checkpoint VISTA with IC50 of 480 nM in FRET assay. |
| PC-38145 |
NSC622608
VISTA inhibitor
|
NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay. |
| PC-35927 |
RRx-001
CD47-SIRPα inhibitor
|
RRx-001 (RRx001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α. |
| PC-62015 |
DRI-C21045
CD40-CD40L inhibitor
|
DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays. |
| PC-22968 |
JNU-0921
CD137 agonist
|
JNU-0921 is a specfiic, small molecule CD137 (4-1BB/TNFRSF9) agonist with EC50 of 64 nM in cell-based luciferase assays, activates both human and mouse CD137, directly binds the extracellular domain of CD137, induces CD137 oligomerizationand activates CD137 signaling. |
