Chemical Structure : CD28 inhibitor CA-23
CAS No.:
2637307-80-1
CD28 inhibitor CA-23
(CA23)
Catalog No.: PC-28452Not For Human Use, Lab Use Only.
CD28 inhibitor CA-23 is a potent, specific small molecule inhibitor of CD28, binds directly to CD28 with MST KD of 0.732 uM, inhibits CD28-B7 engagement and CD28-dependent T cell activation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CD28 inhibitor CA-23 is a potent, specific small molecule inhibitor of CD28, binds directly to CD28 with MST KD of 0.732 uM, inhibits CD28-B7 engagement and CD28-dependent T cell activation.
CA-23 exhibits no detectable binding to CD80, CD86, or CTLA-4 even at 100 uM.
CA-23 inhibits CD28-CD80 and CD28-CD86 interactions with IC50 values of 35.3 nM and 23.9 nM, respectively.
CA-23 inhibits B7 binding to cell-surface CD28, dose-dependently suppresses CD28-mediated T cell activation with an IC50 of 424.4 nM.
CA-23 blocks CD28-driven T cell activation in human blood without independent agonism.
CA-23 (1-10 mg/kg) ameliorates T cell transfer-induced colitis by suppressing pathogenic Th1 and Th17 responses in vivo.
CA-23 suppresses pathogenic cytokine and Th1/Th17 responses in PBMCs from patients with active IBD.
Physicochemical Properties
|
M.Wt
|
393.86
|
|
Formula
|
C17H12ClNO4S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-chloro-N-((1,3-dihydroisobenzofuran-5-yl)sulfonyl)benzo[b]thiophene-2-carboxamide
|
References
1. Cho S, et al. bioRxiv [Preprint]. 2026 Aug 15:2026.08.10.744081.
Contact Us
sales@probechem.com
