| Cat. No. |
Product Name |
Information |
| PC-21773 |
CTLA-4 inhibitor A9.1
CTLA-4 inhibitor
|
CTLA-4 inhibitor A9.1 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 1.4 uM in AlphaLISA assays. |
| PC-21772 |
CTLA-4 inhibitor D11.3
CTLA-4 inhibitor
|
CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays. |
| PC-21719 |
C-5401331
TIM-3 inhibitor
|
C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation. |
| PC-21328 |
Tim-3 inhibitor ML-T7
TIM-3 inhibitor
|
Tim-3 inhibitor ML-T7 is a potent small molecule inhibitor of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), binds to Tim-3 disrupts the interaction of Tim-3 with PtdSer and CEACAM1. |
| PC-21257 |
VISTA inhibitor compound 1
VISTA inhibitor
|
VISTA inhibitor compound 1 is a bifunctional inhibitor targeting VISTA, shows good binding affinity with VISTA (SPR KD=256 nM), induces potent VISTA degradation in HepG2 cells and activates antitumor immunity. |
| PC-21199 |
AG-120-X
ICOS/ICOSL inhibitor
|
AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL. |
| PC-21024 |
TIM-3 inhibitor 38
TIM-3 inhibitor
|
TIM-3 inhibitor 38 is a small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with Ki of 70 nM in FPA competition assays. |
| PC-21023 |
TIM-3 inhibitor A-41
TIM-3 inhibitor
|
TIM-3 inhibitor A-41 is small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with SPR Kd value of 0.61 uM. |
| PC-20828 |
LAG-3 inhibitor SA-15-P
LAG-3 inhibitor
|
LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively. |
| PC-38590 |
M351-0056
VISTA agonist
|
M351-0056 (M351-056) is a small molecule VISTA agonist with high affinity KD of 12.6 uM, inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, regulates type I interferon (IFN-I) and non-canonical NF-κB pathways. |
| PC-38588 |
Compound 6809-0223
VISTA inhibitor
|
Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD). |
| PC-38587 |
L557-0155
VSIG-8/VISTA inhibitor
|
L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth. |
