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TIM-3 inhibitor 38

Chemical Structure : TIM-3 inhibitor 38

CAS No.: 2883237-04-3

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TIM-3 inhibitor 38

Catalog No.: PC-21024Not For Human Use, Lab Use Only.

TIM-3 inhibitor 38 is a small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with Ki of 70 nM in FPA competition assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TIM-3 inhibitor 38 is a small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with Ki of 70 nM in FPA competition assays.

Physicochemical Properties

M.Wt 469.90
Formula C20H16ClN7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=S(C1=NC=CN1)(NC2=CC=C(C3=CC4=C(NC(N5C4=NC(C)=N5)=O)C=C3Cl)C(C)=C2)=O

References

1. Tyson A Rietz, et al. J Med Chem. 2021 Oct 14;64(19):14757-14772.

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