Chemical Structure : DRI-C21095
CAS No.:
2567869-37-6
DRI-C21095
Catalog No.: PC-23563Not For Human Use, Lab Use Only.
DRI-C21095 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.17 uM in cell-free in vitro binding inhibition assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DRI-C21095 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.17 uM in cell-free in vitro binding inhibition assay.
DRI-C21095 displays no activity against TNF-R1–TNF-α interaction.
DRI-C21095 concentration-dependently inhibits CD40L-induced marker expression (CD54, CD86, CD80, MHC-II) in THP cells
DRI-C21095 exhibits concentration-dependent inhibition of CD40L-induced human B-cell function with IC50 of 4.5 uM.
DRI-C21095 concentration-dependently inhibits CD40L-induced B cell proliferation.
DRI-C21095 (30 mg/kg; daily, s.c. in 20% HPβCD) exhibits prolongation of skin allograft in C57BL6 mice, inhibits alloantigen-induced T cell response in a draining lymph node.
Physicochemical Properties
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M.Wt
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656.71
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Formula
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C38H28N2O7S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-(4'-(4'-(methoxycarbonyl)-[1,1'-biphenyl]-4-carboxamido)-[1,1'-biphenyl]-4-carboxamido)naphthalene-1-sulfonic acid
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References
1. Chen J, et al. J Med Chem. (2017) 60:8906–22.
2. Bojadzic D, et al. Molecules. (2018) 23:1153.
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