CTLA-4 inhibitor D11.3

Chemical Structure : CTLA-4 inhibitor D11.3

Catalog No.: PC-21772Not For Human Use, Lab Use Only.

CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays.

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Biological Activity

CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays.
CTLA-4 inhibitor D11.3 (5 mg/kg or 12.5 mg/kg) markedly reduced tumor growth without affecting the body weight in in established syngeneic mouse models expressing transgenic humanized CTLA-4 protein.

Physicochemical Properties

M.Wt	346.86
Formula	C22H19ClN2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole

References

1. Navid Sobhani, et al. BJC Rep. 2024:2:4. doi: 10.1038/s44276-023-00035-5.

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