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CTLA-4 inhibitor D11.3

Chemical Structure : CTLA-4 inhibitor D11.3

CAS No.: 724745-26-0

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CTLA-4 inhibitor D11.3

Catalog No.: PC-21772Not For Human Use, Lab Use Only.

CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays.
    CTLA-4 inhibitor D11.3 (5 mg/kg or 12.5 mg/kg) markedly reduced tumor growth without affecting the body weight in in established syngeneic mouse models expressing transgenic humanized CTLA-4 protein.

    Physicochemical Properties

    M.Wt 346.86
    Formula C22H19ClN2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-benzyl-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole

    References

    1. Navid Sobhani, et al. BJC Rep. 2024:2:4. doi: 10.1038/s44276-023-00035-5.

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