C-5401331 | TIM-3 inhibitor | Probechem Biochemicals

Chemical Structure : C-5401331

C-5401331 (C5401331)

Catalog No.: PC-21719Not For Human Use, Lab Use Only.

C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation.

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Biological Activity

C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation.
C-5401331 inhibits cell viability of THP-1 and HL-60 AML cells with IC50 of 206.6 nM and 318.10 nM respectively.
C-5401331 inhibits Tim-3 and induces early and late phase apoptosis in AML cells.

Physicochemical Properties

M.Wt	332.36
Formula	C24H12O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dibenzo[b,def]chrysene-7,14-dione

References

1. Al Shahrani M, et al. Med Oncol. 2024 Jan 24;41(3):63.

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C-5401331 (C5401331)

Biological Activity

Physicochemical Properties

References

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