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Chemical Structure : VISTA inhibitor compound 1
Catalog No.: PC-21257Not For Human Use, Lab Use Only.
VISTA inhibitor compound 1 is a bifunctional inhibitor targeting VISTA, shows good binding affinity with VISTA (SPR KD=256 nM), induces potent VISTA degradation in HepG2 cells and activates antitumor immunity.
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VISTA inhibitor compound 1 is a bifunctional inhibitor targeting VISTA, shows good binding affinity with VISTA (SPR KD=256 nM), induces potent VISTA degradation in HepG2 cells and activates antitumor immunity.
VISTA inhibitor compound 1 (5 uM) significantly elevates the secretion of IFN-γ in PBMCs, activates antitumor immunity of PBMCs against MDA-MB 231 cells.
VISTA inhibitor compound 1 (10 uM) promotes autophagy-dependent degradation of VISTA through an autophagic pathway in HepG2 cells.
VISTA inhibitor compound 1 (30, 60, or 120 mg/kg) exhibits in vivo antitumor activity in a CT26 mouse model with no obvious body weight loss or mortality during the treatment.
VISTA inhibitor compound 1 significantly increases infiltration of CD8+ cells in tumor tissues in a dose-dependent manner, induces degradation of VISTA, shows better antitumor activity than CA-170 (Cat# PC-72654) at a dose of 60 mg/kg.
| M.Wt | 357.46 | |
| Formula | C23H23N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang T, et al. J Med Chem. 2023 Sep 14;66(17):11881-11892.
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