AG-120-X

Chemical Structure : AG-120-X

Catalog No.: PC-21199Not For Human Use, Lab Use Only.

AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL.

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Biological Activity

Physicochemical Properties

M.Wt	427.89
Formula	C24H18ClN5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(benzylamino)-6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide

References

1. Abdel-Rahman SA, et al. RSC Med Chem. 2023 Aug 1;14(9):1767-1777.

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AG-120-X

Biological Activity

Physicochemical Properties

References

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