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ICOS inhibitor 9

Chemical Structure : ICOS inhibitor 9

CAS No.: 1006002-58-9

ICOS inhibitor 9

Catalog No.: PC-22944Not For Human Use, Lab Use Only.

ICOS inhibitor 9 is a small molecule inhibitor of ICOS/ICOS-L interaction with IC50 of 29.38 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ICOS inhibitor 9 is a small molecule inhibitor of ICOS/ICOS-L interaction with IC50 of 29.38 uM.
Inducible T cell co-stimulator (ICOS) is a positive immune checkpoint receptor expressed on the surface of activated T cells, which could promote cell function after being stimulated with ICOS ligand (ICOS-L).

Physicochemical Properties

M.Wt 349.21
Formula C17H14Cl2N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((3,4-dichlorobenzyl)oxy)-2-methyl-6-(1H-pyrazol-3-yl)phenol

References

1. Zhang L, et al. bioRxiv [Preprint]. 2024 Aug 7:2024.08.04.606538.

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