DRI-C21041

Chemical Structure : DRI-C21041

Catalog No.: PC-23564Not For Human Use, Lab Use Only.

DRI-C21041 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.31 uM in cell-free in vitro binding inhibition assay.

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Biological Activity

DRI-C21041 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.31 uM in cell-free in vitro binding inhibition assay.
DRI-C21041 displays no activity against TNF-R1–TNF-α interaction.
DRI-C21041concentration-dependently inhibits CD40L-induced marker expression (CD54, CD86, CD80, MHC-II) in THP cells
DRI-C21041 exhibits concentration-dependent inhibition of CD40L-induced human B-cell function with IC50 of 13.2 uM.
DRI-C21041 concentration-dependently inhibits CD40L-induced B cell proliferation.

Physicochemical Properties

M.Wt	567.57
Formula	C30H21N3O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4'-(4-nitrobenzamido)-[1,1'-biphenyl]-4-carboxamido)naphthalene-1-sulfonic acid

References

1. Chen J, et al. J Med Chem. (2017) 60:8906–22.

2. Bojadzic D, et al. Molecules. (2018) 23:1153.

DRI-C21041

Biological Activity

Physicochemical Properties

References

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