VISTA inhibitor B3

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Chemical Structure : VISTA inhibitor B3

Catalog No.: PC-24095Not For Human Use, Lab Use Only.

VISTA inhibitor B3 is a potent, small molecule inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) with binding KD of 0.452 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VISTA inhibitor B3 is a potent, small molecule inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) with binding KD of 0.452 uM.
B3 promotes the release of cytokine IL-2 in Jurkat cells and induces VISTA degradation in HepG2 cells.
B3 exhibits favorable oral bioavailability in rats.
B3 (30, 60, and 120 mg/kg, p.o.) significantly inhibited tumor growth in mouse CT-26 subcutaneous transplant tumor model.

Physicochemical Properties

M.Wt	402.52
Formula	C25H27FN4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-(6-(4-fluorophenyl)-7-methyl-1H-benzo[d]imidazol-2-yl)benzyl)-N2,N2-dimethylethane-1,2-diamine

References

1. Qi Z, et al. J Med Chem. 2025 Feb 27. doi: 10.1021/acs.jmedchem.4c02031.

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