MT-110 | Non-muscle myosin II inhibitor

Chemical Structure : MT-110

MT-110 (MT110)

Catalog No.: PC-24900Not For Human Use, Lab Use Only.

MT-110 is a potent, selective, brain penetrant non-muscle myosin II (NMII) inhibitor with EC50 of 0.68 uM in cytokinesis assays, >70-fold selectivity over cardiac muscle myosin II (CMII).

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Biological Activity

MT-110 is a potent, selective, brain penetrant non-muscle myosin II (NMII) inhibitor with EC50 of 0.68 uM in cytokinesis assays, >70-fold selectivity over cardiac muscle myosin II (CMII).
MT-110 exhibits efficacy in preclinical models of methamphetamine use disorder (MUD).
MT-110 is capable of producing persistent disruption of methamphetamine (METH) motivation at doses as low as 0.5 mg/kg.

Physicochemical Properties

M.Wt	371.44
Formula	C23H21N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3a-hydroxy-6,7-dimethyl-1-(2-methylquinolin-6-yl)-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one

References

1. Radnai L, et al. Cell. 2025 Jun 27:S0092-8674(25)00640-3.

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MT-110 (MT110)

Biological Activity

Physicochemical Properties

References

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