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Chemical Structure : MT-134
Catalog No.: PC-72702Not For Human Use, Lab Use Only.
MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members.
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MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members.
MT-134 showed excellent in vivo tolerability, efficacy, and pharmacokinetics.
MT-134 was well-tolerated in mice, impaired motor performance, and had excellent exposure in muscles.
| M.Wt | 348.362 | |
| Formula | C19H16N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laszlo Radnai, et al. ACS Chem Biol. 2021 Nov 19;16(11):2164-2173.
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