Chemical Structure : MT-125
CAS No.:
2404652-80-6
MT-125
(MT125)
Catalog No.: PC-24862Not For Human Use, Lab Use Only.
MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB).
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB).
MT-125 has very limited activity against cardiac myosin II (CMII; KI,CMII = 50 uM).
MT-125 blocks GBM invasion and cytokinesis, and prolongs survival in murine GBM models.
MT-125 increases redox stress and consequent DNA damage, and synergizes with radiotherapy.
MT-125 also induces oncogene addiction to PDGFR signaling through a mechanism that is driven by redox stress, and it synergizes with FDA-approved PDGFR and mTOR inhibitors in vitro.
Combining MT-125 with sunitinib, a PDGFR inhibitor, or paxalisib, a combined phosphatidylinositol 3-kinase (PI3K)/mTOR inhibitor, significantly improves survival in orthotopic GBM models over either drug alone.
Physicochemical Properties
|
M.Wt
|
357.41
|
|
Formula
|
C22H19N3O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-3a-hydroxy-6-methyl-1-(2-methylquinolin-6-yl)-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
|
References
1. Kenchappa RS, et al. Cell. 2025 Jun 3:S0092-8674(25)00569-0.
Contact Us
sales@probechem.com
