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Chemical Structure : Blebbistatin
CAS No.: 674289-55-5
Catalog No.: PC-22347Not For Human Use, Lab Use Only.
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Blebbistatin is a potent and selective non-muscle myosin II (NMII) inhibitor with IC50 of 0.5-5 uM.
Blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.
Blebbistatin inhibits pancreatic adenocarcinoma cellular invasiveness; inhibits some myosin II-independent processes.
Blebbistatin inhibits other activities in the absence of myosin II.
| M.Wt | 292.34 | |
| Formula | C18H16N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one |
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1. Straight AF, et al. Science. 2003 Mar 14;299(5613):1743-7.
2. Abe M, et al. J Biol Chem. 2003 Nov 28;278(48):47707-12.
3. Duxbury MS, et al. Biochem Biophys Res Commun. 2004 Jan 23;313(4):992-7.
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