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Chemical Structure : Mavacamten
CAS No.: 1642288-47-8
Catalog No.: PC-60047Not For Human Use, Lab Use Only.
Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively.
Mavacamten (SAR439152, MYK-461) inhibits α and β isoforms of cardiac myosin with similar activity (IC50=0.3 uM).
Mavacamten (SAR439152, MYK-461) suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain.
| M.Wt | 273.336 | |
| Formula | C15H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione |
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1. Green EM, et al. Science. 2016 Feb 5;351(6273):617-21.
2. Stern JA, et al. PLoS One. 2016 Dec 14;11(12):e0168407.
3. Kawas RF, et al. J Biol Chem. 2017 Oct 6;292(40):16571-16577.
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