| Cat. No. |
Product Name |
Information |
| PC-42527 |
JNJ-7706621
CDK/Aurora inhibitor
|
JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively. |
| PC-24695 |
FCN-437c
CDK4/6 inhibitor
|
FCN-437c (FCN-437) is a potent, selective and orally active inhibitor of CDK4/6, shows selective inhibitory activities against CDK4/6 over other CDKs. |
| PC-24657 |
Bireociclib
CDK4/6 inhibitor
|
Bireociclib (XZP-3287) is a novel potent, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor with IC50 of 2.7/16 nM respectively. |
| PC-24595 |
MRT-9643
CDK2 degrader
|
MRT-9643 (MRT9643) is a potent, selective and orally active CDK2-directed molecular glue degrader, induces CDK2-dependent cancer cell growth inhibition. |
| PC-24530 |
Tagtociclib hydrate
CDK2 inhibitor
|
Tagtociclib hydrate (PF-07104091) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
| PC-24494 |
Y041-2712
CDK8 inhibitor
|
Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins. |
| PC-24482 |
LA-CB1
CDK4/6 degrader
|
LA-CB1 is a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, exerts robust anti-proliferative effects across a wide spectrum of cancer cell lines (A498 cell, IC50=0.21 uM). |
| PC-24325 |
SNX631-6
CDK8/19 inhibitor
|
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively. |
| PC-24231 |
YJZ5118
CDK12/13 inhibitor
|
YJZ5118 is a potent, highly selective covalent inhibitor of CDK12/13 with IC50 of 39.5/26.4 nM, respectively, demonstrates high selectivity over other CDKs. |
| PC-24198 |
Zeltociclib
CDK7 inhibitor
|
Zeltociclib is a potent, specific CDK7 inhibitor. |
| PC-24041 |
F059-1017
CDK8 inhibitor
|
F059-1017 is a potent, selective CDK8 inhibitor with IC50 of 558.1 nM, reduces phosphorylation and expression of signaling mediators associated with inflammation. |
| PC-23981 |
Arcyriaflavin A
CDK4 inhibitor
|
Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells. |
