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Cat. No. Product Name Information
PC-42036

LY3177833

CDC7 inhibitor

LY3177833 is a potent and selective CDC7 inhibitor with IC50 of 3.3 nM.
PC-42060

AZD-5438

CDK1/2/9 inhibitor

AZD-5438 (AZD5438) potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively.
PC-42425

Senexin B

CDK8/CDK19 inhibitor

Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM.
PC-42527

JNJ-7706621

CDK/Aurora inhibitor

JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively.
PC-24960

Mocaciclib

CDK7 inhibitor

Mocaciclib (Q901) is a highly selective and potent CDK7 inhibitor, forms a covalent bond with C312 of the CDK7 C-terminal domain.
PC-24915

AS3334366

CDK8/19 inhibitor, Foxp3 inducer

AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM.
PC-24914

AS2863619

CDK8/19 inhibitor, Foxp3 inducer

AS2863619 is a potent, selective and orally active inhibitor of CDK8 and CDK19 with IC50 of 0.61 nM and 4.28 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 32.5 nM.
PC-24695

FCN-437c

CDK4/6 inhibitor

FCN-437c (FCN-437) is a potent, selective and orally active inhibitor of CDK4/6, shows selective inhibitory activities against CDK4/6 over other CDKs.
PC-24657

Bireociclib

CDK4/6 inhibitor

Bireociclib (XZP-3287) is a novel potent, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor with IC50 of 2.7/16 nM respectively.
PC-24595

MRT-9643

CDK2 degrader

MRT-9643 (MRT9643) is a potent, selective and orally active CDK2-directed molecular glue degrader, induces CDK2-dependent cancer cell growth inhibition.
PC-24494

Y041-2712

CDK8 inhibitor

Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins.
PC-24482

LA-CB1

CDK4/6 degrader

LA-CB1 is a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, exerts robust anti-proliferative effects across a wide spectrum of cancer cell lines (A498 cell, IC50=0.21 uM).

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