| Cat. No. |
Product Name |
Information |
| PC-35688 |
JSH-150
CDK9 inhibitor
|
JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM). |
| PC-35631 |
iCDK9
CDK9 inhibitor
|
iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC. |
| PC-35630 |
Amt-87
|
Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186. |
| PC-35532 |
Compound 919278
CDK12 inhibitor
|
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK. |
| PC-35525 |
CDK12 inhibitor 2
CDK12 inhibitor
|
CDK12 inhibitor 2 is (CDK12-IN-2) is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9. |
| PC-35361 |
BAY-320
BUB1 inhibitor
|
BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM. |
| PC-35250 |
AZD4573
CDK9 inhibitor
|
AZD4573 (AZD-4573) is a potent and selective inhibitor of CDK9 with IC50 of <4 nM, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. |
| PC-35248 |
Cdc7 inhibitor X
Cdc7 inhibitor
|
Cdc7 inhibitor X is a potent inhibitor of Cdc7 kinase with pIC50 of 10.01 against CDC7/DBF4 in TR-FRET assays. |
| PC-35095 |
ICEC 0942 hydrochloride
CDK7 inhibitor
|
ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM). |
| PC-43446 |
BS-181 hydrochloride
CDK7 inhibitor
|
BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM). |
| PC-43445 |
BS-181
CDK7 inhibitor
|
BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM). |
| PC-63464 |
JH-VIII-49
CDK8 inhibitor
|
JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM). |
