| Cat. No. |
Product Name |
Information |
| PC-35361 |
BAY-320
BUB1 inhibitor
|
BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM. |
| PC-35250 |
AZD4573
CDK9 inhibitor
|
AZD4573 (AZD-4573) is a potent and selective inhibitor of CDK9 with IC50 of <4 nM, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. |
| PC-35248 |
Cdc7 inhibitor X
Cdc7 inhibitor
|
Cdc7 inhibitor X is a potent inhibitor of Cdc7 kinase with pIC50 of 10.01 against CDC7/DBF4 in TR-FRET assays. |
| PC-35095 |
ICEC 0942 hydrochloride
CDK7 inhibitor
|
ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM). |
| PC-43446 |
BS-181 hydrochloride
CDK7 inhibitor
|
BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM). |
| PC-43445 |
BS-181
CDK7 inhibitor
|
BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM). |
| PC-63464 |
JH-VIII-49
CDK8 inhibitor
|
JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM). |
| PC-63455 |
FIT-039
CDK9 inhibitor
|
FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM). |
| PC-63452 |
RO5454291
CDK5-p25 inhibitor
|
RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction with IC50 of 1.39 uM.. |
| PC-63451 |
RO5258638
CDK5-p25 inhibitor
|
RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction.. |
| PC-63305 |
HSD992
CDK2/3 inhibitor
|
HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively. |
| PC-63252 |
BI-1347
CDK8/CDK19 inhibitor
|
BI-1347 is a potent, selective inhibitor of CDK8/CDK19 with IC50 of 1.4 nM/1.9 nM, respectively. |
