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Chemical Structure : Amt-87
Catalog No.: PC-35630Not For Human Use, Lab Use Only.
Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186.
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Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186.
Amt-87 induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter.
Amt-87 synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription.
| M.Wt | 492.612 | |
| Formula | C30H36O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wu J, et al. Sci Rep. 2017 Sep 6;7(1):10657.
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