| Cat. No. |
Product Name |
Information |
| PC-63127 |
Enitociclib
CDK9 inhibitor
|
Enitociclib ((±)-BAY-1251152) is a potent, highly specific P-TEFb/CDK9 inhibitor with IC50 of 3 nM. displays> 50-fold selectivity against other CDKs. |
| PC-63039 |
Apcin
APC inhibitor
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
| PC-62864 |
CAN-508
CDK9 inhibitor
|
CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM). |
| PC-62848 |
CDK9-IN-4d
CDK9 inhibitor
|
CDK9-IN-4d is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition. |
| PC-62821 |
CGP-74514A hydrochloride
CDK1 inhibitor
|
CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM. |
| PC-62682 |
Ibulocydine
CDK7/9 inhibitor
|
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively. |
| PC-62680 |
NSC 625987
CDK4 inhibitor
|
NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). |
| PC-62678 |
Ryuvidine
CDK4 inhibitor, SETD8 inhibitor
|
Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM). |
| PC-62677 |
PNU-112455A
CDK2/5 inhibitor
|
PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-Met, IGR-1R, and ERK2. |
| PC-62573 |
CDK5 inhibitor 20-223
CDK5 inhibitor
|
CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9. |
| PC-62561 |
CCT068127
CDK2/9 inhibitor
|
CCT068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively. |
| PC-62534 |
IIIM-290
CDK2/9 inhibitor
|
IIIM-290 (IIIM290) is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively. |
