| Cat. No. |
Product Name |
Information |
| PC-42944 |
THZ2
CDK7 inhibitor
|
THZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1. |
| PC-63139 |
TAK-931
Cdc7 inhibitor
|
TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM. |
| PC-63127 |
Enitociclib
CDK9 inhibitor
|
Enitociclib ((±)-BAY-1251152) is a potent, highly specific P-TEFb/CDK9 inhibitor with IC50 of 3 nM. displays> 50-fold selectivity against other CDKs. |
| PC-63041 |
TAME hydrochloride
APC/C inhibitor
|
TAME hydrochloride is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1). |
| PC-63040 |
proTAME
APC/C inhibitor
|
proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20). |
| PC-63039 |
Apcin
APC/C inhibitor
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
| PC-62864 |
CAN-508
CDK9 inhibitor
|
CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM). |
| PC-62848 |
CDK9-IN-4d
CDK9 inhibitor
|
CDK9-IN-4d is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition. |
| PC-62821 |
CGP-74514A hydrochloride
CDK1 inhibitor
|
CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM. |
| PC-62682 |
Ibulocydine
CDK7/9 inhibitor
|
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively. |
| PC-62680 |
NSC 625987
CDK4 inhibitor
|
NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). |
| PC-62678 |
Ryuvidine
CDK4 inhibitor, SETD8 inhibitor
|
Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM). |
