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Chemical Structure : Ro-3306
CAS No.: 872573-93-8
Catalog No.: PC-43098Not For Human Use, Lab Use Only.
Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.
Ro-3306 also inhibits CDK1/cyclin A complexes with Ki of 110 nM, shows >15-fold selectivity against a diverse panel of 8 human kinases.
Ro-3306 reversibly arrests human cells at the G(2)/M border of the cell cycle and allows for effective cell synchronization in early mitosis.
Ro-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
| M.Wt | 351.4453 | |
| Formula | C18H13N3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- |
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1. Vassilev LT, et al. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.
2. Kojima K, et al. Cancer Sci. 2009 Jun;100(6):1128-36.
3. Krasinska L, et al. Cell Cycle. 2008 Jun 15;7(12):1702-8.
4. Vassilev LT. Cell Cycle. 2006 Nov;5(22):2555-6.
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