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Chemical Structure : TAME hydrochloride
Catalog No.: PC-63041Not For Human Use, Lab Use Only.
TAME is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1).
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TAME is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1); inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM; promotes Cdc20 autoubiquitination, blocks cyclin degradation in interphase extract.
| M.Wt | 378.87 | |
| Formula | C14H22N4O4S.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang S, et al. Nature. 2016 May 12;533(7602):260-264.
2. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95.
3. Zeng X, et al. Nat Chem Biol. 2012 Feb 26;8(4):383-92.
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