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Chemical Structure : CDKI-73
CAS No.: 1421693-22-2
Catalog No.: PC-43037Not For Human Use, Lab Use Only.
Asnuciclib (CDKI-73) is a potent CDK9 inhibitor with Ki of 4 nM, shows cytotoxicity against a broad CLL samples with mean LD50 of 80 nM.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
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Asnuciclib (CDKI-73) is a potent CDK9 inhibitor with Ki of 4 nM, shows cytotoxicity against a broad CLL samples with mean LD50 of 80 nM.
CDKI-73 induces caspase-dependent apoptosis that was preceded by dephosphorylation of CDK9 and serine 2 of RNA polymerase II.
CDKI-73 is more potent than the pan-CDK inhibitor Flavopiridol and shows >200-fold selectivity against primary leukemia cells when compared with normal CD34+ cells.
CDKI-73 shows cytotoxic synergy with the nucleoside analog fludarabine in in poor prognostic sub-groups of leukemia patients, which is associated with CDKI-73-mediated transcriptional inhibition of MCL1 and XIAP.
| M.Wt | 394.447 | |
| Formula | C15H15FN6O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenesulfonamide, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]- |
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1. Walsby E, et al. Oncotarget. 2014 Jan 30;5(2):375-85.
2. Lam F, et al. Oncotarget. 2014 Sep 15;5(17):7691-704.
3. Cao S, et al. Biochem Biophys Res Commun. 2017 Jan 22;482(4):536-541.
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