| Cat. No. |
Product Name |
Information |
| PC-46008 |
THZ1
CDK7 inhibitor
|
THZ1 is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM, also weakly inhibits CDK12 with IC50 of 250 nM. |
| PC-42578 |
PHA-848125
CDK/TRK inhibitor
|
Milciclib (PHA-848125) is a potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively. |
| PC-42067 |
R547
CDK inhibitor
|
R547 is a potent, selective and ATP-competitive CDK inhibitor with Ki of 1/3/1 nM for CDK1/2/4, respectively. |
| PC-45446 |
Purvalanol B
CDK inhibitor
|
Purvalanol B (NG-95) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively. |
| PC-45447 |
Purvalanol A
CDK inhibitor
|
Purvalanol A (NG-60) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. |
| PC-42050 |
Flavopiridol hydrochloride
CDK inhibitor
|
Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively. |
| PC-42049 |
Flavopiridol
CDK inhibitor
|
Flavopiridol (HMR-1275, Alvocidib) is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively. |
| PC-42777 |
PHA-793887
CDK inhibitor
|
PHA-793887 is a potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively, >6-fold less potency on CDK1/4/6. |
| PC-45913 |
AT-7519 hydrochloride
CDK2 inhibitor
|
AT-7519 hydrochloride (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM). |
| PC-45912 |
AT-7519 trifluoroacetate
CDK2 inhibitor
|
AT-7519 trifluoroacetate (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM). |
| PC-45911 |
AT-7519
CDK2 inhibitor
|
AT-7519 (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM). |
| PC-45863 |
Palbociclib hydrochloride
CDK4/6 inhibitor
|
Palbociclib (PD0332991) hydrochloride is a potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. |
