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Fascaplysin chloride

Chemical Structure : Fascaplysin chloride

CAS No.: 114719-57-2

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Fascaplysin chloride (NSC 622398)

Catalog No.: PC-60480Not For Human Use, Lab Use Only.

Fascaplysin chloride (NSC 622398) is a potent CDK4/cyclin D1 with IC50 of 0.35 uM, 10-fold less potent for significantly for CDK6/cyclin D1 and does not inhibit other Cdks and tyrosine kinases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Fascaplysin chloride (NSC 622398) is a potent CDK4/cyclin D1 with IC50 of 0.35 uM, 10-fold less potent for significantly for CDK6/cyclin D1 and does not inhibit other Cdks and tyrosine kinases.
    Fascaplysin chloride shows antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest.
    Fascaplysin chloride induces PPARγ-1α deacetylation with IC50 of 0.7 uM.

    Physicochemical Properties

    M.Wt 306.8
    Formula C18H11N2OCl
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium, monochloride

    References

    1. Soni R, et al. Biochem Biophys Res Commun. 2000 Sep 7;275(3):877-84.

    2. Lee Y, et al. Nature. 2014 Jun 26;510(7506):547-51.

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