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Chemical Structure : Voruciclib
CAS No.: 1000023-04-0
Catalog No.: PC-61031Not For Human Use, Lab Use Only.
Voruciclib (P1446A-05) is a potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $498 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Voruciclib (P1446A-05) is a potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively.
Voruciclib (P1446A-05) also inhibits CDK6/cyclin D1, CDK4/cyclin D1, CDK1/cyclin B and CDK1/cyclin A with Ki of 3-10 nM, shows weak activity against MAK and ICK (Ki>250 nM).
Voruciclib (P1446A-05) exhibits more selective target profile than flavopiridol, represses MCL-1 protein expression in preclinical models of DLBCL.
Voruciclib (P1446A-05) causes tumor cell apoptosis and tumor growth inhibition combined with venetoclax in vivo.
| M.Wt | 469.841 | |
| Formula | C22H19ClF3NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one |
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1. Dey J, et al. Sci Rep. 2017 Dec 21;7(1):18007.
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