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Cat. No. Product Name Information
PC-42578

PHA-848125

CDK/TRK inhibitor

Milciclib (PHA-848125) is a potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively.
PC-45913

AT-7519 hydrochloride

CDK2 inhibitor

AT-7519 hydrochloride (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).
PC-45912

AT-7519 trifluoroacetate

CDK2 inhibitor

AT-7519 trifluoroacetate (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).
PC-45911

AT-7519

CDK2 inhibitor

AT-7519 (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).
PC-42052

SNS-032

CDK2/7/9 inhibitor

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
PC-42616

Dinaciclib

CDK inhibitor

Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
PC-42425

Senexin B

CDK8/CDK19 inhibitor

Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM.
PC-42527

JNJ-7706621

CDK/Aurora inhibitor

JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively.
PC-22032

KY-273

CDK8/19 inhibitor

KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7  nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects.
PC-21964

dCeMM4

Cyclin K degrader

dCeMM4 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
PC-21963

dCeMM3

Cyclin K degrader

dCeMM3 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
PC-21962

dCeMM2

Cyclin K degrader

dCeMM2 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.

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