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Chemical Structure : FIT-039
CAS No.: 1113044-49-7
Catalog No.: PC-63455Not For Human Use, Lab Use Only.
FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).
FIT-039 shows no marked inhibitory effect on CDK4/cyclinD3, does not inhibit other CDKs, including CDK2/cyclinB1, CDK2/cyclinE1, CDK5/p25, CDK6/cyclinD3, or CDK7/cyclinH/MAT.
FIT-039 suppresses viral replication without affecting the host cell cycle, inhibits viral transcription; also inhibits HBV propagation and HIV-1 replication.
FIT-039 suppresses HPV viral oncogenes E6 and E7, and shows therapeutic rffect on HPV-induced neoplasia in vivo.
| M.Wt | 315.41 | |
| Formula | C17H18FN3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide |
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1. Yamamoto M, et al. J Clin Invest. 2014 Aug;124(8):3479-88.
2. Okamoto M, et al. Antiviral Res. 2015 Nov;123:1-4.
3. Tanaka T, et al. Antiviral Res. 2016 Sep;133:156-64.
4. Ajiro M, et al. Clin Cancer Res. 2018 Apr 30. pii: clincanres.3119.2017.
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