| Cat. No. |
Product Name |
Information |
| PC-21089 |
RGB-286638
CDK inhibitor
|
RGB-286638 is a small-molecule multi-targeted cyclin-dependent kinase (CDK) inhibitor with IC50 of 1-5 nM for cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5. |
| PC-21088 |
LDC000067
CDK9 inhibitor
|
LDC000067 (LDC067) is a highly specific inhibitor of CDK9 with IC50 of 44 nM (CDK9-Cyclin T1), highly selective over other CDKs in the range of 55-fold (CDK2) to over 230-fold (CDK6 and CDK7). |
| PC-21053 |
HQ461
cyclin K degrader
|
HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM. |
| PC-21051 |
SW394703
cyclin K degrader
|
SW394703 is a novel DDB1-dependent molecular glue degrader for cyclin K, SW394703 is toxic to HCT116 cells (IC50=1.2 uM). |
| PC-20880 |
CAF-382
CDKL5 inhibitor
|
CAF-382 (SGC-CAF382-1) is a potent, specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) with IC50 of 11 nM in NanoBRET assays, shows no activity against GSK3β. |
| PC-20872 |
Ribociclib
CDK4/6 inhibitor
|
Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively. |
| PC-20691 |
NCGC00131308
IQGAP1-Cdc42 inhibitor
|
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays. |
| PC-20589 |
Abemaciclib
CDK4/6 inhibitor
|
Abemaciclib (LY2835219) is a potent, selective and ATP-competitive CDK4/6 inhibitor with Ki values of 0.6 and 2.4 nM for CDK4/cyclin D1 and CDK6/cyclin D1, respectively. |
| PC-20566 |
Apcin-A
APC inhibitor, Cdc20 inhibitor
|
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. |
| PC-20494 |
Cdk5i peptide
Cdk5/p25 inhibitor
|
Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone. |
| PC-20345 |
Cdc25A inhibitor 7h
Cdc25A inhibitor
|
Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20344 |
Cdc25A inhibitor 7g
Cdc25A inhibitor
|
Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
