| Cat. No. |
Product Name |
Information |
| PC-20494 |
Cdk5i peptide
Cdk5/p25 inhibitor
|
Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone. |
| PC-20345 |
Cdc25A inhibitor 7h
Cdc25A inhibitor
|
Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20344 |
Cdc25A inhibitor 7g
Cdc25A inhibitor
|
Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20316 |
LDC4297
CDK7 inhibitor
|
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM). |
| PC-20315 |
LGR6768
CDK7 inhibitor
|
LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs. |
| PC-20284 |
QR-6401
CDK2 inhibitor
|
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor. |
| PC-20283 |
PF-07104091
CDK2 inhibitor
|
PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers. |
| PC-20219 |
CDK8 inhibitor 32
CDK8 inhibitor
|
CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone. |
| PC-49792 |
SGC-CDKL5/GSK3-1
CDKL5/GSK3 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
| PC-49789 |
RGB-286147
CDK inhibitor
|
RGB-286147 (RGB 286147) is a proteome-wide CDK/CRK-specific kinase inhibitor with IC50 of 48 and 15 nM for CDK1/CycB and CDK2/CycE, respectively. |
| PC-49785 |
ISM042-2-048
CDK20 inhibitor
|
ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM. |
| PC-49575 |
PF-07220060
CDK4 inhibitor
|
PF-07220060 (Atirmociclib) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3). |
