| Cat. No. |
Product Name |
Information |
| PC-23060 |
Tacaciclib
CDK7 inhibitor
|
Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor. |
| PC-23058 |
BPI-16350
CDK4/6 inhibitor
|
BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM). |
| PC-23019 |
YK-2168
CDK9 inhibitor
|
YK-2168 is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2. |
| PC-22380 |
CDK9 inhibitor VC-1
CDK9 inhibitor
|
CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5. |
| PC-22118 |
AZD8421
CDK2 inhibitor
|
AZD8421 (AZD-8421) is a potent, highly selective CDK2 inhibitor with IC50 of 9 nM, >300-fold selectivity over CDK9. |
| PC-21886 |
CVT-313
CDK2 inhibitor
|
CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E. |
| PC-21681 |
XPW1
CDK9 inhibitor
|
XPW1 is a potent and selective CDK9 inhibitor with excellent anti-ccRCC activity and low toxicity. |
| PC-21562 |
GFH009
CDK9 inhibitor
|
GFH009 (Tambiciclib, GFH-009) is a potent, highly selective CDK9 inhibitor with IC50 of 9 nM against CDK9/Cyclin T1 complex, blocks RNAP2-mediated transcription maturation. |
| PC-21527 |
TMX-2039
pan CDK inhibitor
|
TMX-2039 is a pan-CDK inhibitor with low nanomolar enzymatic IC50s (0.5-50 nM) for both cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). |
| PC-21500 |
INX-315
CDK2 inhibitor
|
INX-315 (INX315) is a highly potent, selective CDK2 inhibitor with IC50 of 0.6 and 2.5 nM for CDK2/cyclin E1 and CDK2/cyclin A2 respectively, shows high selectivity over other CDK family members. |
| PC-21462 |
CDDD11-8
CDK9/FLT3-ITD inhibitor
|
CDDD11-8 is a potent, selective, orally bioavailable CDK9 inhibitor with Ki of 8 nM, shows >50-fold selectivity over other CDKs, also inhibits FLT3-ITD with Ki of 13 nM. |
| PC-21140 |
Cyclin K degrader DS17
cyclin K degarder
|
Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM. |
