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Chemical Structure : Ribociclib
CAS No.: 1211441-98-3
Catalog No.: PC-20872Not For Human Use, Lab Use Only.
Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively.
Ribociclib suppresses neuroblastoma growth in vitro with IC50 of 306 nM against 12 of the 17 neuroblastoma cell lines.
Ribociclib causes cell-cycle arrest and cellular senescence and dose-dependently decreases in phosphorylated RB and FOXM1, respectively.
Ribociclib (200 mg/kg ) causes tumor growth delay in vivo in neuroblastoma cell-line derived xenografts.
| M.Wt | 434.55 | |
| Formula | C23H30N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
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1. Rader J, et al. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.
2. Zhang YX, et al. Mol Cancer Ther. 2014 Sep;13(9):2184-93.
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